Current Topics In Human Genetics: Studies In Complex DiseasesHong-wen Deng, Hui Shen, Yongjun Liu, Hai Hu The sequencing of the human genome has brought human genetics into a new era of study resulting in the generation of an explosive amount of information. Application of genomic, proteomic, and bioinformatics technologies to the study of human genetics has made it possible for human genetic diseases to be studied on an unprecedented scale, both in silico and in the wet lab. This volume provides up-to-date coverage of the broad range of research topics in this fascinating area. In the first part of the book, a whole spectrum of approaches to human genetics research is reviewed for both background and the latest progress. In the second, important topics related to genetic research of various complex human diseases are discussed. The robust content and diverse array of subjects allow the book to serve as both a concise “encyclopedia” that introduces basic and essential concepts of human genetics and an in-depth review of the current understanding of genetic research in human diseases. |
Contents
| 1 | |
| 21 | |
| 37 | |
| 65 | |
5 Tag SNP Selection and Its Applications in Association Studies Kui Zhang and Fengzhu Sun | 95 |
6 Haplotype Inference and Association Analysis in Unrelated Samples Zeny Feng Nianjun Liu and Hongyu Zhao | 123 |
7 A Survey on Haplotyping Algorithms for Tightly Linked Markers Jing Li | 161 |
Methods and Applications in Association Studies Jiexun Wang Guohua Zou and Hongyu Zhao | 179 |
Concepts Databases Software Tools and Biomedical Implications SudhaRani Mamidipalli and Jake Yue Chen | 539 |
20 Genomic Cloning in the Postgenome Era Yan Jiao and Weikuan Gu | 563 |
21 RNA Metabolism and Human Diseases Zhongwei Li and Gayatri Kollipara | 581 |
22 Recent Progress in the Genetics of Osteoporosis Hui Shen YongJun Liu Peng Xiao DongHai Xiong and HongWen Deng | 617 |
23 Critical Molecules in Bone Development and Genetic Bone Diseases Qing Wang Ming Zhang Tianhui Zhu and Di Chen | 655 |
24 Genetic Factors for Human Type 1 Diabetes CongYi Wang Junyan Han and JinXiong She | 693 |
25 Genetic Susceptibility to Human Obesity YongJun Liu and HongWen Deng | 729 |
26 Genes in Estrogen Metabolism Pathway and Breast Cancer JiRong Long | 759 |
9 Linkage Disequilibrium and Test for Interaction Between Two Loci Momiao Xiong | 209 |
10 Association Tests for Complex Disease Genes While Controlling Population Stratification Shuanglin Zhang and Qiuying Sha | 255 |
11 Statistical Methods for Multiple QTL Mapping in Experimental Crosses Daniel Shriner Solomon Musani and Nengjun Yi | 285 |
12 Animal Models in the Study of Genetics of Complex Human Diseases Weikuan Gu Jian Yan and Yan Jiao | 325 |
13 Acquisition of Accurate Gene Expression Information from Microarray Measurements Shuang Jia Shouguo Gao Martin J Hessner and Xujing Wa... | 351 |
14 Application of DNA Microarray Technology in Genetics Jian Yan Weikuan Gu and Yan Jiao | 375 |
15 Expression Quantitative Trait Locus eQTL Mapping Song Huang David Ballard Zheyang Wu and Hongyu Zhao | 397 |
Causal Pathways from DNA to Complex Traits Yan Cui | 433 |
17 Functional Proteomics and Its Application in Biomedical Sciences Guishan Xiao and Teri Zhang | 449 |
18 An Introduction to Biomedical Informatics Hai Hu and Michael N Liebman | 499 |
27 Hereditary Breast and Ovarian Cancers Wentao Yang Daren Shi and Jinsong Liu | 773 |
28 Activation of Wnt Signaling in Tumor Development Zhimin Lu | 809 |
MHC and Beyond Yahuan Lou | 833 |
30 Genetics of Substance Dependence Joel Gelernter and Henry R Kranzler | 865 |
31 Insulin Resistance and Metabolic Syndrome WeiDong Li and R Arlen Price | 883 |
Multiorganellar Defects Wei Li | 929 |
Author Index | 945 |
Subject Index | 947 |
Other editions - View all
Current Topics in Human Genetics: Studies in Complex Diseases Hong-wen Deng,Hui Shen Limited preview - 2007 |
Common terms and phrases
Acad Sci USA algorithm allele frequencies approach arrays association studies autoimmune diseases Bayesian Bioinformatics Biol Bone Miner Res BRCA1 BRCA2 breast cancer candidate genes case-control cells chromosome clinical correlation database density detect developed distribution DNA pooling effects estimated factors function gene expression Genet Epidemiol genomewide genotype genotype data haplotype haplotype block haplotype frequencies haplotype inference Hum Genet human genome identified individuals insulin levels linkage analysis linkage disequilibrium locus LRP5 markers metabolism methods mice microarray molecular mouse mRNA multiple mutations Nat Genet Natl Acad Sci nucleotide obesity osteoblast ovarian cancer pairs pathway phenotypes polymorphisms population stratification Proc Natl Acad protein protein interaction proteomics QTL mapping quantitative trait loci receptor recombination region regression regulation risk Runx2 sample sequence single nucleotide polymorphisms structure susceptibility genes syndrome tag SNP selection tion tissue transcription tumors type 2 diabetes unlinked variation Zhang